Jingyu Dong

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...