Jinghao Sheng

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

Abstract Whether and how disrupted cholesterol homeostasis contributes to alcohol-related liver disease (ALD) remains elusive. Here, we report that cholesterol biosynthesis is enhanced in ALD livers, driven by a reduction in the H3K9me2 epigenetic landscape orchestrated by the G9...