Jing Tian

Targeting chondroitin synthase 1 attenuates hyperplastic arterial remodeling via gene therapy

Chondroitin sulfate glycosaminoglycans accumulate excessively in the extracellular matrix during pathological remodeling and exacerbate cardiovascular deterioration. Here we show that chondroitin synthase 1 (CHSY1) is the primary enzyme responsible for chondroitin sulfate synthes...

The stroke crisis in ageing societies: global trends, risk factors, and clinical validation

Stroke remains a major global public health challenge, particularly among the elderly population. This study aims to integrate MIMIC-IV clinical data with GBD 2021 data to analyse epidemiological trends and regional differences in stroke among people aged 70 and above, identify k...