Jing Dai

High sperm DNA fragmentation is associated with increased embryonic chromosomal abnormality: a retrospective study of 8 years involving 5637 couples undergoing ART

Abstract STUDY QUESTION Does sperm DNA fragmentation impair blastocyst chromosomal integrity? SUMMARY ANSWER A high sperm DNA fragmentation index (DFI) is associated with an increased risk of blastocyst aneuploidy, particularly when the man has poor semen quality or when the fema...

Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker Cohorts

Objective: To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts. Methods: We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and exter...