Jinbo Zhao

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

Development and internal validation of a prediction model for early anastomotic leak after minimally invasive esophagectomy: a prospective cohort study

Background Anastomotic leak (AL) remains a complication after minimally invasive esophagectomy (MIE), affecting 10–20% of patients and increasing morbidity and mortality. Although local conduit perfusion and systemic nutritional status are central to anastomotic healing, no valid...