Jin Xiong

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme Fe IV =O Complexes: An Enthalpy‐Entropy Compensation Effect

ABSTRACT Synthetic nonheme Fe IV ═O complexes reported thus far often have S = 1 ground states, demonstrating markedly lower oxidative reactivity in C─H bond breakage compared to their S = 2 counterparts. Recently, we have identified that incorporating cycloalkyl groups into the...

Protein Thioether Crosslinks Installed by a SPASM-Containing Radical SAM Enzyme from Methanogenic Archaea

Abstract Cysteine is a vital amino acid with wide biological utility, serving functions in catalysis, ligand binding, and maintenance of protein structures. In a subset of natural products, termed ribosomally synthesized and post-translationally modified peptides (RiPPs), multipl...