Jieru Han

Identification and bioinformatic functional annotation of circRNAs mediating phenotypic differences in hair follicle cycling of Jinlan cashmere goats

Circular RNAs (circRNAs) act as critical regulators of hair follicle development, but how they mediate phenotypic divergence of hair growth in cashmere goats remains largely unclear. In this study, skin transcriptome analysis was conducted to screen differentially expressed circR...

The Mechano-Immune-Vascular Activation Loop: An Integrative Conceptual Framework for Positive Feedback in Hypertension

Hypertension is increasingly recognized as involving chronic inflammation beyond its hemodynamic origins. This review proposes the Mechano-Immune-Vascular Activation Loop as an integrative conceptual framework—a positive feedback circuit in which aberrant mechanical forces in the...

Lactate as a Master Regulator of Immune Suppression: From Metabolic Waste to Epigenetic Checkpoint in Colorectal Cancer

Colorectal cancer, especially the microsatellite-stable subtype, which accounts for 85% to 95% of cases, resists immune checkpoint inhibitors largely due to metabolic reprogramming in the tumor microenvironment. Lactate has evolved from a waste product into a central immunosuppre...