Jie Yan

Retinoic acid maintains the primordial follicle reserve by inhibiting PI3K/Akt signaling

In female mammals, nonrenewable primordial follicles are orderly activated to maintain reproductive lifespan. However, the initiating regulator(s) of primordial follicle maintenance and activation remain poorly characterized. RA synthesis enzymes were mainly expressed in the pre-...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...