Jie Wang

“Trojan”Methionine Probe Reveals PKM2as a Methionine-Sensing Protein in the mTORC1 Pathway

Abstract Methionine (Met) plays a pivotal role in numerous cellular functions. Methionine restriction has been demonstrated to provide metabolic benefits in aging, obesity, diabetes and as an adjunct to cancer therapy. However, the methionine-sensing proteins and how cells direct...