Jie Tian

Naphthalimide-based andrographolide nanoplatform suppresses ccRCC via targeting the HIF-2α/VEGF signaling axis

Constitutive activation of hypoxia-inducible factor-2α (HIF-2α) is a central oncogenic driver in clear cell renal cell carcinoma (ccRCC). In this work, a naphthalimide-based multifunctional nanoplatform was developed as a drug delivery system for andrographolide (AG) to improve i...

3D NIR-II FMT-XCT imaging for quantitative analysis of PD-L1 expression in lung cancer and tumor-draining lymph nodes facilitating immunotherapy efficacy assessment: an exploratory study

Abstract Background Accurate evaluation of programmed death-ligand 1 (PD-L1) expression is crucial for guiding immunotherapy in lung cancer. Conventional biopsy-based immunohistochemistry (IHC) fails to capture the spatial and temporal heterogeneity of PD-L1 expression. This stud...