Jie Lu

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Multiple organ failure following severe heat stroke complicated by AMSAN-type Guillain-Barré syndrome: a case report and literature review

Heat stroke is a severe form of heat-related injury that can provoke a systemic inflammatory response and cytokine storm, disrupting immune homeostasis. Guillain–Barré syndrome (GBS) has rarely been reported during recovery from heat stroke, and the nature of this association rem...

A fully automated deep learning pipeline system for carotid plaque segmentation and vulnerability classification on multi-contrast MRI: a multicenter study

Abstract Background Carotid vulnerable plaque rupture is a major cause of ischemic stroke. However, accurate identification of high-risk plaques using medical images heavily relies on radiologists’ expertise. This study aimed to develop an artificial intelligence (AI) system for...

Thrombus molecular markers and thromboelastogram as early predictors of venous thromboembolism after total knee arthroplasty in perioperative elderly patients

Elderly patients undergoing total knee arthroplasty have a higher incidence of venous thromboembolism (VTE) owing to age, surgical trauma, and other factors. Numerous studies have employed the Caprini scale and d -dimer levels to evaluate perioperative coagulation function and pr...

FOCUS: a feature optimization and cascaded unified screening strategy for computer-aided pathology-based glioma molecular subtype classification

Abstract Background Accurate classification of Isocitrate Dehydrogenase (IDH) mutation status is crucial for the diagnosis and treatment of adult-type diffuse gliomas as defined by the 2021 World Health Organization (WHO) Classification. However, conventional histological and mol...

Investigating Associations Between Signal Intensity of Silent MR Angiography and Hemodynamic Information From 4D Flow MRI in Brain Arteriovenous Malformation

BACKGROUND: Whether signal intensity (SI) on Silent MRA reflects hemodynamics in brain arteriovenous malformations (BAVMs) is unclear. OBJECTIVES: To evaluate the relationship between Silent MRA SI and 4D flow-derived hemodynamic parameters and examine whether Silent MRA-based me...