Jie Han

Exercise-associated transcriptomic profiling identifies Ticam2 as a candidate therapeutic target in a SOD1G93A mouse model of amyotrophic lateral sclerosis

Exercise may slow disease progression in amyotrophic lateral sclerosis (ALS), but the molecular mechanisms underlying its protective effects remain unclear. Here, voluntary wheel running prolonged survival in male SOD1 G93A mice. To identify potentially actionable molecular targe...