Jiayuan Wu

Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function

Background FXI (Factor XI) inhibitors have emerged as a promising antithrombotic strategy. However, a recent study linked decreased FXI levels with increased risk of heart failure (HF) and atrial fibrillation (AF), particularly in older adults. This study aims to investigate the...

Identifying potential macrophage polarization-related causal genes in sepsis through multi-omics mendelian randomization analysis and experimental validation

The genetic associations between macrophage polarization-related genes (MPGs) and sepsis remain unclear. This study aimed to identify sepsis-associated MPGs. Based on blood-derived methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data for...