Jiayu Yan

Integrative multi-omics analysis implicates RSAD2-associated CXCL1–CXCR1/2 signaling in tumor–macrophage communication and progression of endometrial cancer

Immunotherapy in endometrial cancer (EC) faces challenges due to patient-specific heterogeneity and biomarkers linking tumor-intrinsic programs to the tumor microenvironment remain limited. This study aimed to identify immune-related prognostic factors and investigate the role of...

p21 Inhibition Rescues Radiation‐Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb–Smad2/3–Runx2 Axis

ABSTRACT Background Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation‐induced DNA damage, but its role in ORNJ remains unknown. Methods An ORNJ mouse model was established. Single‐cell...