Jiaying Ni

Hepatic PDIA5 improves hyperglycaemia and insulin resistance through stabilisation of ATF6

Dysregulation of hepatic glucose production, primarily driven by aberrantly elevated gluconeogenesis, is a core pathological feature of type 2 diabetes. However, the molecular mechanisms governing this process remain incompletely understood. Protein disulfide isomerase A5 (PDIA5)...