Jiayin Wang

A semi-supervised deep learning framework (TBMNet) for automatic tumor budding quantification: real-world validation and clinical utility in stage II colorectal cancer

Abstract Background Tumor budding (TB) is a clinically important prognostic marker in colorectal cancer (CRC), but its assessment remains subjective and its biological basis is incompletely understood. We developed an artificial intelligence (AI)-based TB evaluation framework and...

Bisphenol A and Its Substitutes Bisphenol S/Bisphenol F in Combined Exposure Collectively Exacerbate Hepatotoxicity by Triggering Oxidative Stress and Inflammatory Responses via the PI3K-Akt/NF-κB Axis

Abstract Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are environmental endocrine-disrupting chemicals that frequently co-occur. However, the hepatotoxic effects and underlying mechanisms of their combined exposure remain unclear. This study integ...

Rapid Colorimetric Detection of Free and Complexed Cr3+ Based on a Tetrabutylphosphonium Bromide/Gold Nanoparticle Anti-Aggregation System

Existing colorimetric sensing strategies based on gold nanoparticles (AuNPs) are largely limited to the detection of free metal ions, leaving metal-organic complexes widely present in real water bodies undetectable. Herein, we develop a simple colorimetric method based on the ant...