Jiayi Tao

Temporal Single-Nucleus Transcriptomics Defines PPARα/CPT1A-Associated Metabolic Reprogramming During Proximal Tubular Injury and Repair

Background: Metabolic reprogramming and mitochondrial dysfunction are central features of acute kidney injury (AKI), yet their temporal relationship with proximal tubular cell-state remodeling remains incompletely understood. This study aimed to characterize early metabolic alter...