Jiatong Li

Dual-color Imaging of Cell-Surface and Intracellular Proteins Using Fluorescent Probes for β-lactamase Tag

Abstract We herein develop a fluorescein-conjugated β-lactamase inhibitor-based probe, FD-DA, with expanded emission color for labeling proteins through β-lactamase tag. FD-DA specifically labeled intracellular target proteins in live cells after hydrolysis of the ester groups. I...

pH-Responsive Probe for β-Lactamase-based Protein Tag in Fluorescence Imaging of Receptor Endocytosis

Abstract Fluorescence imaging of the local pH environment surrounding proteins offers an understanding of cellular processes, including receptor endocytosis. We herein develop a pH-responsive fluorescent β-lactamase inhibitor for protein labeling via a genetically encodable β-lac...