Jiaqi Wang

An oncolytic virus armed with fowl adenovirus fiber-modified recombinant TRAIL enhances tumor targeting and immunotherapy activity

Oncolytic viruses have emerged as a promising strategy in cancer immunotherapy and have been applied to the treatment of various tumors. We previously demonstrated that oncolytic adenoviruses engineered expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) co...

In Situ Multiscale Imaging Reveals Cellular Selection and Remodeling of Peptide Assemblies from Membrane Perturbation to Actin Dysregulation

Abstract Enzyme-responsive peptide nanomaterials can induce non-apoptotic cancer cell death, yet the supramolecular states that mediate activity in cellular environments are usually inferred rather than directly resolved. Here, we integrate multiscale in situ imaging with biochem...

Caragana korshinskii Tannin Attenuates LPS-Induced Sheep Rumen Epithelial Injury via TLR4/MyD88/NF-κB Signaling

The rumen epithelium mediates nutrient absorption and mucosal defense in ruminants, whereas increased exposure to lipopolysaccharide (LPS) under high-concentrate feeding may induce epithelial inflammation and barrier injury. This study investigated whether Caragana korshinskii ta...