Jiaqi Pu

Asymmetric Copper-Catalyzed Propargylation of 5-Aminopyrazoles with Propargylic Acetates

Abstract An asymmetric copper-catalyzed propargylic substitution reaction of propargylic acetates with ambident 5-aminopyrazoles was developed. Under optimized conditions, the relevant products with a wide range of substrates and good functional tolerance were obtained in 51–98%...