Jianye Yang

Targeting SIRT2-mediated mitophagy to enhance ferroptosis: a novel mechanism of berberine action in non-small cell lung cancer

INTRODUCTION: Berberine (BBR), a natural isoquinoline alkaloid, has been shown to specifically bind to sirtuin 2 (SIRT2) and exhibit anticancer activity. This study aimed to elucidate the therapeutic mechanisms of BBR in non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: A...