Jianxin Wang

Targeting Distinct Cell Cycle Nodes Overcomes RAS Inhibitor Resistance

Activating mutations in KRAS drive pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC). Although mutant-selective KRAS inhibitors and pan-RAS inhibitors provide clinical benefits, the development of resistance limits durable responses. Here, transcripto...