Jianxin Lyu

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Performance of a five-gene plasma cfDNA methylation assay for colorectal cancer detection: a single-center real-world analysis

Blood-based circulating cell-free DNA (cfDNA) methylation assays have been proposed as minimally invasive tools for colorectal cancer (CRC) detection, but their performance under routine clinical conditions may differ from model-development studies. We evaluated the real-world di...