Jianwen Zhou

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

Neutrophil Extracellular Trap-Derived DNA Activates the ITGB1/FAK Pathway to Promote Lung Adenocarcinoma Metastasis

Abstract Neutrophil extracellular traps (NETs) have recently emerged as key modulators of cancer progression and metastasis. However, a more comprehensive understanding of the underlying mechanisms could help identify effective strategies to prevent and treat NET-mediated metasta...