Jianqiang Yang

MUC5B orchestrates tobacco-driven metabolic rewiring and immunosuppression in head and neck squamous cell carcinoma

Abstract Background Tobacco exposure is a major risk factor for HPV-unrelated head and neck squamous cell carcinoma (HNSCC) and is associated with poor clinical outcomes; however, the molecular regulators through which tobacco exposure drives tumor aggressiveness and immunosuppre...

Reprogramming the tumor immune landscape through SPP1 targeting

Abstract Beyond its canonical roles in bone mineralization and extracellular matrix remodeling, secreted phosphoprotein 1 (SPP1) has emerged as a central regulator of the tumor microenvironment (TME), orchestrating immunosuppressive programs that drive immune evasion and tumor pr...