Jianmin Wu

Machine Learning Empowers Enzyme Discovery, Structure Prediction, Engineering, and Design

Abstract Enzymes are efficient and selective biocatalysts, yet obtaining enzymes with desired properties remains challenging due to vast sequence spaces, incomplete functional annotation, limited structural information, and costly experimental screening. Machine learning (ML) off...

Code–Test Co-translation: Towards Practical and Effective Program Migration in the Wild

Program migration, which involves translating software systems from one programming language to another, is essential for modernizing legacy systems and improving maintainability. Recent large language models (LLMs) have demonstrated strong performance in code translation; howeve...

Preparation of Uniform Nonspherical PLGA Particles in the Nanosize Range by Using a Two-Step Premix Membrane Emulsification Technique

Abstract The shape of polymeric particulate systems is a critical determinant of their in vivo fate, and nonspherical nanoparticles are promising candidates for advanced drug delivery. However, spherical-shaped particles are usually produced by conventional emulsion-based methods...

Sodium Lidar observed multiple sodium layer structures and their dynamical coupling mechanism

Abstract. On the night of 13 June 2013, the University of Science and Technology of China (USTC) sodium lidar observed multiple sporadic sodium layers (SSLs) and enhanced sodium patterns (ESPs) over Hefei, China (31.8°N, 117.3°E). These structures appeared at different times, col...