Jian‐Liang Ye

FeBr3-Catalyzed Aromatization-C–O Bond Cleavage Process for Construction of Aryl-Substituted Prostaglandin Skeleton

Abstract Prostaglandins exhibit therapeutic potential in multiple diseases and the incorporation of aromatic rings into their side chains can often enhance their corresponding biological activities. Although more than 20 kinds of drugs are currently used in clinical practice, the...

N -Acyl Hemiperaminals: From Bioactive Skeleton Editing of Artemisinin to Programmable Handles for α-Amido Functionalization and Bioactive Peroxides

Abstract Late-stage molecular editing is vital for drug diversification and SAR studies. However, programmable peroxide-based editing handles for amides, α-amino acids, peptide- and drug-relevant scaffolds remain largely unexplored, particularly N-acyl hemiperaminals. Inspired by...