Jianjun Mu

Cumulative TyG-related indices in relation to incident arterial stiffness and carotid intima-media thickening: a 6-year follow-up within the 36-year Hanzhong adolescent hypertension cohort

Abstract Background Insulin resistance promotes both arterial stiffening and carotid atherosclerosis, but the comparative value of TyG-related indices for these phenotypes is unclear. Using a cohort with childhood anthropometry measured in 1987, we compared two vascular phenotype...

High salt activates the mineralocorticoid receptor-RUNX1 axis to mediate renal injury via mitochondrial dysfunction

Abstract Background Excessive salt intake contributes to salt-sensitive hypertension and renal injury in part through aberrant activation of the mineralocorticoid receptor (MR). While mitochondrial dysfunction is increasingly implicated in salt-induced target-organ damage, the tr...