Jiangyuan Zhang

Mechanistic investigation of keratinocyte injury induced by the small-molecule PD-L1 inhibitor BMS-1 via network toxicology, molecular dynamics simulation and cellular assays

Abstract Background Programmed cell death ligand 1 (PD-L1) inhibitors are important agents for lung cancer immunotherapy. However, they frequently cause cutaneous toxicity in clinical practice, which compromises therapeutic compliance. Current studies mostly focus on immune cells...