Jiangning Song

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Epitope-conditioned generation of T-cell receptor β-chain CDR3 candidates using a pre-trained transformer model

Prioritizing T-cell receptor (TCR) candidates for defined peptide-HLA targets is an important step in TCR-based immunotherapy development, but it still relies heavily on laborious and expensive experimental screening. Recent advancements in generative artificial intelligence have...