Jianfei He

First Total Syntheses of Both C10 Epimers of Mycenolide A: Stereochemical Assignment and Reassessment of Its Reported Neuroprotective Activity

Abstract Mycenolide A, a marine-derived 5-substituted butenolide, possesses a remote C10 quaternary stereocenter whose absolute configuration was previously unassigned. Herein, we report the first stereodivergent total syntheses of both C10-epimers of mycenolide A in only nine st...