Jiancong Ni

An i-Motif Conformational Transition Synergizing with pH-Responsive Reduced Graphene Oxide Field-Effect Transistor for Urease Activity Sensing

Abstract Urease serves as a key diagnostic biomarker, whose abnormal activity is closely associated with oral diseases such as caries and periodontitis. However, detecting trace urease in saliva remains technically challenging. In this work, we report for the first time a C4-rGO-...

Allosteric Switching-Triggered Electrocatalyst Recruitment Enables Indicator-Free, Milliampere-Level Hydrogen Evolution Readout for MicroRNA-21 Detection

Abstract Electrochemical nucleic acid biosensors typically rely on redox labels or exogenous mediators to generate analytical signals, which can complicate assay design and constrain signal magnitude. Herein, we report an enzyme-free and indicator-free electrochemical biosensor f...