Jian-Zhong Xu

Evolution of (S)-2-Aminobutanol Synthesis from Chemical Resolution to Biomanufacturing

As a pivotal chiral precursor for the synthesis of the antituberculosis drug ethambutol and antiepileptic drugs such as levetiracetam, Chiral (S)-2-aminobutanol requires high optical purity for clinical safety. This review systematically summarizes the evolution and recent advanc...