Jian Wen

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...