Jian Lyu

Medial Temporal Atrophy and Posterior Cingulate Structural Covariance in Mild Cognitive Impairment

BACKGROUND: Mild cognitive impairment (MCI) is associated with structural abnormalities in regions vulnerable to Alzheimer's disease, but the relative contributions of medial temporal, posterior midline, and association cortices remain unclear. We compared regional gray matter vo...

Disentangling global atrophy burden from local structural patterns reveals clinically relevant heterogeneity in mild cognitive impairment

Abstract Background Mild cognitive impairment (MCI) is a heterogeneous prodromal stage of Alzheimer’s disease (AD). Imaging-based subtyping studies, however, often confound overall disease severity with local anatomical variation, limiting biological interpretability and clinical...