Jian Li

Polyamine metabolism related prognostic genes and risk model in prostate cancer insights into tumor microenvironment and drug sensitivity

Abstract Background Polyamine metabolism (PM) is linked to the progression and prognosis of several cancers, but the specific mechanism of Polyamine metabolism-related genes (PMRGs) in Prostate carcinoma (PCa) is not fully understood. This study aims to construct and validate a P...

Mechanism-Guided Antimicrobial Peptide Design through Membrane-Surface Fingerprinting and Graph Diffusion

Abstract Antimicrobial peptides (AMPs) are promising antibiotic alternatives, but current AI-based discovery often relies on sequence labels and lacks explicit modeling of peptide–membrane interactions. We developed Membrane-MaSIF, an MD-derived membrane surface matching model de...