Jiajia Lu

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage. In this study, we developed pH‐responsive ZIF‐90 nanoparticles loaded with puerarin (PU) (ZIF‐90@PU) for microenvironment‐responsive osteoporosi...