Jia-Neng Xu

Engineering an ( R )‐Selective Transaminase for High‐Substrate‐Loading Asymmetric Amination of a Sterically Demanding N ‐Heterocyclic Ketone

ABSTRACT The biocatalytic asymmetric amination of bulky N ‐heterocyclic ketones is often limited by low enzyme activity and poor performance at high substrate loading. Herein, we developed an efficient ( R )‐selective transaminase for the synthesis of ( R )‐1‐Boc‐3‐aminopiperidin...