Jia Ling Tiffany Yeo

Human iPSC-derived motor neurons with TDP-43 nuclear loss present early ALS pathological phenotypes

Abstract Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by progressive loss of motor neurons and presents a critical need for effective treatments. To investigate the impact of TAR DNA-binding protein 43 (TDP-43) nuclear depletion in ALS...