Jessica S. Blackburn

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models

Phosphatase of regenerating liver 3 (PRL-3) is a cancer-associated protein linked to tumor progression, metastasis, and poor patient outcomes, but the mechanism underlying its oncogenic activity remains unresolved. PRL-3 functions both as a phosphatase and as a binding partner of...