Jessica M. Grein

PPM1H loss alters intrasynaptic alpha-synuclein localization in a LRRK2-dependent manner

Abstract Mutations in the LRRK2 gene are a major genetic cause of Parkinson’s disease (PD) and induce hyperphosphorylation of RAB GTPases through increased LRRK2 kinase activity. The phosphatase PPM1H counteracts this activity by selectively dephosphorylating LRRK2-phosphorylated...