Jessica J. Hayward

A homozygous hypomorphic FBN1 splice region variant in domestic cats with Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant connective tissue disease caused by variants in the fibrillin 1 ( FBN1 ) gene. While common in humans, spontaneous animal models are rarely reported. We present the first phenotypic and molecular characterization of MFS in domestic c...

Establishment of Patient-Derived Xenotransplant and Cell Line Models for Canine B-Cell Lymphoma

High-grade canine B-cell lymphoma (cBCL) is a spontaneous cancer in dogs with similar pathologic features as human diffuse large B-cell lymphoma (DLBCL). The value of comparative oncology to both dogs and humans has long been recognized, but the progress in cBCL research has been...