Jessica E. Pullan

Variable IL13Rα2 Expression Across Glioblastoma Models and Tumor Regions

Background: Interleukin-13 Receptor alpha 2 (IL13Rα2) is an attractive therapeutic target for glioblastoma because of its limited expression in normal brain tissue and overexpression in many tumors. However, the spatial heterogeneity of glioblastoma and limitations of conventiona...

Integrated Transcriptomic Analysis Reveals Coordinated Gliovascular Remodeling Across Diffuse Glioma Grades

Background: The gliovascular unit forms the structural and functional basis of the glymphatic system, which facilitates cerebrospinal fluid–interstitial fluid exchange to maintain brain homeostasis. Although disruption of individual astrocytic, vascular, and extracellular matrix...