Jess Nigro

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

Abstract Background Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, and mutations in PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) and BAG3 (proline to lysine at position 209, P209L...