Jeong Taeg Seo

Repurposing irosustat for malaria: host-targeted antiplasmodial activity via cholesterol sulfate modulation against drug-resistant Plasmodium falciparum

Abstract Background The urgent global need for novel antimalarial drugs targeting Plasmodium falciparum has intensified due to rising mortality and drug resistance. This study examines a host-directed strategy targeting lipid metabolism by evaluating the antiplasmodial activity o...

NatD promotes glioblastoma progression through epigenetic activation of FGFR4 signalling

Abstract N-terminal acetyltransferase D (NatD) acetylates histones H4 and H2A at serine 1 and has been implicated in oncogenesis, yet its role in glioblastoma (GBM) remains unexplored. Here, we show that NatD expression is significantly elevated in GBM at both transcript and prot...