Jennifer R. S. Meadows

ABCB1 Frameshift Deletion in Skye Terriers With Potential Pharmacogenetic Relevance

Ivermectin-associated neurotoxicity is a potentially life-threatening condition caused by disruption of the ABCB1 encoded P-glycoprotein drug transporter in certain dog breeds. Skye terriers are considered at increased risk of ivermectin toxicity despite the absence of an identif...

Towards a Standard Threshold for Genome Wide Significance in Dogs

ABSTRACT Genome‐wide association studies (GWAS) are a foundational step in tying phenotype to genotype, relying on statistical significance thresholds to distinguish true‐ from false‐positive signals of association. Dog genomics has long relied on per‐study Bonferroni thresholds...