Jennie Wilson

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

encodes an enzyme responsible for the catalytic transfer of N-acetylglucosamine to phosphatidylinositol during the first step of glycosylphosphatidylinositol anchor biosynthesis. Loss of this enzyme has a widespread phenotypic impact, but primarily results in neurological symptom...