Jenkins E.

ROS/HIF-1 signalling in alveolar macrophages: implications for lung fibrosis

Alveolar macrophages (AMs) in idiopathic pulmonary fibrosis (IPF) display stabilisation of hypoxia inducible factor (HIF)-1 despite their residence within the well oxygenated alveolar space. This highlights a contradiction between oxygen supply and hypoxic signalling in the fibr...