Jeffrey O’Callaghan

Autotaxin induces fibrosis in lamina cribrosa cells in glaucoma

Lysophosphatidic acid (LPA) and the enzyme that generates it, autotaxin, have been shown to play a role in fibrosis in the trabecular meshwork in glaucoma, contributing to increased intraocular pressure. We wished to investigate the role of LPA and autotaxin in fibrosis of the la...