Jeffrey N. Johnston

Umpolung Amide Synthesis with Nitrosoalkane Electrophiles: Pursuit of the Elusive N -Acyl Nitrone for Dipolar Cycloadditions

Abstract Nitrones are reactive dipoles for cycloadditions that have been used for powerful alkene difunctionalization reactions, often stereocontrolled. Despite the wealth of knowledge generated over a half-century of study, reports of N-acyl nitrones are exceedingly rare, with l...